Bibliografía
2020
Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1
Herkenne S, Ek O, Zamberlan M, Pellattiero A, Chergova M, Chivite I, Novotná E, Rigoni G, Fonseca TB, Samardzic D, Agnellini A, Bean C, Di Benedetto G, Tiso N, Argenton F, Viola A, Soriano ME, Giacomello M, Ziviani E, Sales G, Claret M, Graupera M, Scorrano L.
Cell Metab. 2020 Apr 17. pii: S1550-4131(20)30189-3. doi: 10.1016/j.cmet.2020.04.007.
Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer.
Hermanova I, Zúñiga-García P, Caro-Maldonado A, Fernandez-Ruiz S, Salvador F, Martín-Martín N, Zabala-Letona A, Nuñez-Olle M, Torrano V, Camacho L, Lizcano JM, Talamillo A, Carreira S, Gurel B, Cortazar AR, Guiu M, López JI, Martinez-Romero A, Astobiza I, Valcarcel-Jimenez L, Lorente M, Arruabarrena-Aristorena A, Velasco G, Gomez-Muñoz A, Suárez-Cabrera C, Lodewijk I, Flores JM, Sutherland JD, Barrio R, de Bono JS, Paramio JM, Trka J, Graupera M, Gomis RR, Carracedo A.
J Exp Med. 2020 Jun 1;217(6). pii: e20191787. doi: 10.1084/jem.20191787.
PI3Kβ-Regulated Pericyte Maturation Governs Vascular Remodeling.
Figueiredo AM, Villacampa P, Diéguez-Hurtado R, Lozano JJ, Kobialka P, Cortazar AR, Martinez-Romero A, Angulo-Urarte A, Franco CA, Claret M, Aransay AM, Adams RH, Carracedo A, Graupera M.
Circulation. 2020 May 29. doi: 10.1161.
Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation.
Martinez-Corral I, Zhang Y, Petkova M, Ortsäter H, Sjöberg S, Castillo SD, Brouillard P, Libbrecht L, Saur D, Graupera M, Alitalo K, Boon L, Vikkula M, Mäkinen T.
Nat Commun. 2020 Jun 8;11(1):2869. doi: 10.1038/s41467-020-16496-y.
2019
Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer
Di Mitri D, Mirenda M, Vasilevska J, Calcinotto A, Delaleu N, Revandkar A, Gil V, Boysen G, Losa M, Mosole S, Pasquini E, D’Antuono R, Masetti M, Zagato E, Chiorino G, Ostano P, Rinaldi A, Gnetti L, Graupera M, Martins Figueiredo Fonseca AR, Pereira Mestre R, Waugh D, Barry S, De Bono J, Alimonti A.
Cell Rep. 2019 Aug 20;28(8):2156-2168.e5.
Antitumor Effects of Anti-Semaphorin 4D Antibody Unravel a Novel Proinvasive Mechanism of Vascular-Targeting Agents.
Zuazo-Gaztelu I, Pàez-Ribes M, Carrasco P, Martín L, Soler A, Martínez-Lozano M, Pons R, Llena J, Palomero L, Graupera M, Casanovas O.
Cancer Res. 2019 Oct 15;79(20):5328-5341.
PIK3CA mutations in vascular malformations
Castillo SD, Baselga E, Graupera M.
Curr Opin Hematol. 2019 May;26(3):170-178.
2018
Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility
Angulo-Urarte A, Casado P, Castillo SD, Kobialka P, Kotini MP, Figueiredo AM, Castel P, Rajeeve V, Milà-Guasch M, Millan J, Wiesner C, Serra H, Muixi L, Casanovas O, Viñals F, Affolter M, Gerhardt H, Huveneers S, Belting HG, Cutillas PR, Graupera M.
Nat Commun. 2018 Nov
Integrative analysis of transcriptomics and clinical data uncovers the tumor-suppressive activity of MITF in prostate cancer
Valcarcel-Jimenez L, Macchia A, Martín-Martín N, Cortazar AR, Schaub-Clerigué A, Pujana-Vaquerizo M, Fernández-Ruiz S, Lacasa-Viscasillas I, Santos-Martin A, Loizaga-Iriarte A, Unda-Urzaiz M, Hermanova I, Astobiza I, Graupera M, Starkova J, Sutherland J, Barrio R, Aransay AM, Carracedo A, Torrano V.
Cell Death Dis. 2018 Oct
Endothelial Cells: New Players in Obesity and Related Metabolic Disorders
Graupera M, Claret M.
Trends Endocrinol Metab. 2018 Nov. Review
DYRK1A Kinase Positively Regulates Angiogenic Responses in Endothelial Cells
Rozen EJ, Roewenstrunk J, Barallobre MJ, Di Vona C, Jung C, Figueiredo AF, Luna J, Fillat C, Arbonés ML, Graupera M, Valverde MA, de la Luna S.
Cell Rep. 2018 May
ALK1 Loss Results in Vascular Hyperplasia in Mice and Humans Through PI3K Activation
Alsina-Sanchís E, García-Ibáñez Y, Figueiredo AM, Riera-Domingo C, Figueras A, Matias-Guiu X, Casanovas O, Botella LM, Pujana MA, Riera-Mestre A, Graupera M, Viñals F.
Arterioscler Thromb Vasc Biol. 2018 May.
A Role for CXCR4 in Peritoneal and Hematogenous Ovarian Cancer Dissemination
Figueras A, Alsina-Sanchís E, Lahiguera Á, Abreu M, Muinelo-Romay L, Moreno-Bueno G, Casanovas O, Graupera M, Matias-Guiu X, Vidal A, Villanueva A, Viñals F.
Mol Cancer Ther. 2018 Feb;17(2):532-543.
2017
Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling
Berenjeno IM, Piñeiro R, Castillo SD, Pearce W, McGranahan N, Dewhurst SM, Meniel V, Birkbak NJ, Lau E, Sansregret L, Morelli D, Kanu N, Srinivas S, Graupera M, Parker VER, Montgomery KG, Moniz LS, Scudamore CL, Phillips WA, Semple RK, Clarke A, Swanton C, Vanhaesebroeck B.
Nat Commun. 2017 Nov.
Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition
Mateo F, Arenas EJ, Aguilar H, Serra-Musach J, de Garibay GR, Boni J, Maicas M, Du S, Iorio F, Herranz-Ors C, Islam A, Prado X, Llorente A, Petit A, Vidal A, Català I, Soler T, Venturas G, Rojo-Sebastian A, Serra H, Cuadras D, Blanco I, Lozano J, Canals F, Sieuwerts AM, de Weerd V, Look MP, Puertas S, García N, Perkins AS, Bonifaci N, Skowron M, Gómez-Baldó L, Hernández V, Martínez-Aranda A, Martínez-Iniesta M, Serrat X, Cerón J, Brunet J, Barretina MP, Gil M, Falo C, Fernández A, Morilla I, Pernas S, Plà MJ, Andreu X, Seguí MA, Ballester R, Castellà E, Nellist M, Morales S, Valls J, Velasco A, Matias-Guiu X, Figueras A, Sánchez-Mut JV, Sánchez-Céspedes M, Cordero A, Gómez-Miragaya J, Palomero L, Gómez A, Gajewski TF, Cohen EEW, Jesiotr M, Bodnar L, Quintela-Fandino M, López-Bigas N, Valdés-Mas R, Puente XS, Viñals F, Casanovas O, Graupera M, Hernández-Losa J, Ramón Y Cajal S, García-Alonso L, Saez-Rodriguez J, Esteller M, Sierra A, Martín-Martín N, Matheu A, Carracedo A, González-Suárez E, Nanjundan M, Cortés J, Lázaro C, Odero MD, Martens JWM, Moreno-Bueno G, Barcellos-Hoff MH, Villanueva A, Gomis RR, Pujana MA.
Oncogene. 2017 May 11;36(19):2737-2749.
Resistance to Targeted Therapies in Renal Cancer: The Importance of Changing the Mechanism of Action
Duran I, Lambea J, Maroto P, González-Larriba JL, Flores L, Granados-Principal S, Graupera M, Sáez B, Vivancos A, Casanovas O.
Target Oncol. 2017 Feb;12(1):19-35. doi: 10.1007/s11523-016-0463-4. Review.
2016
PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia
Ola R, Dubrac A, Han J, Zhang F, Fang JS, Larrivée B, Lee M, Urarte AA, Kraehling JR, Genet G, Hirschi KK, Sessa WC, Canals FV, Graupera M, Yan M, Young LH, Oh PS, Eichmann A.
Nat Commun. 2016 Nov 29;7:13650.
Therapeutic Benefit of Selective Inhibition of p110α PI3-Kinase in Pancreatic Neuroendocrine Tumors
Soler A, Figueiredo AM, Castel P, Martin L, Monelli E, Angulo-Urarte A, Milà-Guasch M, Viñals F, Baselga J, Casanovas O, Graupera M.
Clin Cancer Res. 2016 Dec 1;22(23):5805-5817. Epub 2016 May 25.
Targeting PI3K in Cancer: Impact on Tumor Cells, Their Protective Stroma, Angiogenesis, and Immunotherapy
Okkenhaug K, Graupera M, Vanhaesebroeck B.
Cancer Discov. 2016 Oct;6(10):1090-1105. Epub 2016 Sep 21. Review.
The TGFβ pathway stimulates ovarian cancer cell proliferation by increasing IGF1R levels
Alsina-Sanchis E, Figueras A, Lahiguera Á, Vidal A, Casanovas O, Graupera M, Villanueva A, Viñals F.
Int J Cancer. 2016 Oct 15;139(8):1894-903.
The metabolic co-regulator PGC1α suppresses prostate cancer metastasis
Torrano V, Valcarcel-Jimenez L, Cortazar AR, Liu X, Urosevic J, Castillo-Martin M, Fernández-Ruiz S, Morciano G, Caro-Maldonado A, Guiu M, Zúñiga-García P, Graupera M, Bellmunt A, Pandya P, Lorente M, Martín-Martín N, Sutherland JD, Sanchez-Mosquera P, Bozal-Basterra L, Zabala-Letona A, Arruabarrena-Aristorena A, Berenguer A, Embade N, Ugalde-Olano A, Lacasa-Viscasillas I, Loizaga-Iriarte A, Unda-Urzaiz M, Schultz N, Aransay AM, Sanz-Moreno V, Barrio R, Velasco G, Pinton P, Cordon-Cardo C, Locasale JW, Gomis RR, Carracedo A.
Nat Cell Biol. 2016 Jun;18(6):645-656.
Resistance to Antiangiogenic Therapies by Metabolic Symbiosis in Renal Cell Carcinoma PDX Models and Patients
Jiménez-Valerio G, Martínez-Lozano M, Bassani N, Vidal A, Ochoa-de-Olza M, Suárez C, García-Del-Muro X, Carles J, Viñals F, Graupera M, Indraccolo S, Casanovas O.
Cell Rep. 2016 May 10;15(6):1134-43.
Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans
Castillo SD, Tzouanacou E, Zaw-Thin M, Berenjeno IM, Parker VE, Chivite I, Milà-Guasch M, Pearce W, Solomon I, Angulo-Urarte A, Figueiredo AM, Dewhurst RE, Knox RG, Clark GR, Scudamore CL, Badar A, Kalber TL, Foster J, Stuckey DJ, David AL, Phillips WA, Lythgoe MF, Wilson V, Semple RK, Sebire NJ, Kinsler VA, Graupera M, Vanhaesebroeck B.
Sci Transl Med. 2016 Mar 30;8(332):332ra43.
Class I PI-3-Kinase Signaling Is Critical for Bone Formation Through Regulation of SMAD1 Activity in Osteoblasts
Gámez B, Rodríguez-Carballo E, Graupera M, Rosa JL, Ventura F.
J Bone Miner Res. 2016 Aug;31(8):1617-30.
Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic Expression of Vascular Endothelial Growth Factor and Angiogenesis in Chronic Liver Disease
Calderone V, Gallego J, Fernandez-Miranda G, Garcia-Pras E, Maillo C, Berzigotti A, Mejias M, Bava FA, Angulo-Urarte A, Graupera M, Navarro P, Bosch J, Fernandez M, Mendez R.
Gastroenterology. 2016 Apr;150(4):982-97.e30.
2015
PTEN mediates Notch-dependent stalk cell arrest in angiogenesis
Serra H, Chivite I, Angulo-Urarte A, Soler A, Sutherland JD, Arruabarrena-Aristorena A, Ragab A, Lim R, Malumbres M, Fruttiger M, Potente M, Serrano M, Fabra À, Viñals F, Casanovas O, Pandolfi PP, Bigas A, Carracedo A, Gerhardt H, Graupera M.
Nat Commun. 2015 Jul 31;6:7935.
Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells
Guillermet-Guibert J, Smith LB, Halet G, Whitehead MA, Pearce W, Rebourcet D, León K, Crépieux P, Nock G, Strömstedt M, Enerback M, Chelala C, Graupera M, Carroll J, Cosulich S, Saunders PT, Huhtaniemi I, Vanhaesebroeck B.
PLoS Genet. 2015 Jul 1;11(7):e1005304.
PI3K at the crossroads of tumor angiogenesis signaling pathways
Soler A, Angulo-Urarte A, Graupera M.
Mol Cell Oncol. 2015 Feb 26;2(2):e975624. doi: 10.4161/23723556.2014.975624. eCollection 2015 Apr-Jun. Review.
cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels
Stanczuk L, Martinez-Corral I, Ulvmar MH, Zhang Y, Laviña B, Fruttiger M, Adams RH, Saur D, Betsholtz C, Ortega S, Alitalo K, Graupera M, Mäkinen T.
Cell Rep. 2015 Mar 17;10(10):1708-1721.
2014
The PDGFRβ-AKT pathway contributes to CDDP-acquired resistance in testicular germ cell tumors
Juliachs M, Muñoz C, Moutinho CA, Vidal A, Condom E, Esteller M, Graupera M, Casanovas O, Germà JR, Villanueva A, Viñals F.
Clin Cancer Res. 2014 Feb 1;20(3):658-67.
2013
Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis
Soler A, Serra H, Pearce W, Angulo A, Guillermet-Guibert J, Friedman LS, Viñals F, Gerhardt H, Casanovas O, Graupera M, Vanhaesebroeck B.
J Exp Med. 2013 Sep 23;210(10):1937-45.
Effectivity of pazopanib treatment in orthotopic models of human testicular germ cell tumors.
Juliachs M, Vidal A, Del Muro XG, Piulats JM, Condom E, Casanovas O, Graupera M, Germà JR, Villanueva A, Viñals F.
BMC Cancer. 2013 Aug 10;13:382.
Metronomic chemotherapy following the maximum tolerated dose is an effective anti-tumour therapy affecting angiogenesis, tumour dissemination and cancer stem cells
Vives M, Ginestà MM, Gracova K, Graupera M, Casanovas O, Capellà G, Serrano T, Laquente B, Viñals F.
Int J Cancer. 2013 Nov 15;133(10):2464-72.
Regulation of angiogenesis by PI3K signaling networks
Graupera M, Potente M.
Exp Cell Res. 2013 May 15;319(9):1348-55. Review.
ErbBs inhibition by lapatinib blocks tumor growth in an orthotopic model of human testicular germ cell tumor
Juliachs M, Castillo-Ávila W, Vidal A, Piulats JM, Garcia Del Muro X, Condom E, Hernández-Losa J, Teixidó C, Pandiella A, Graupera M, Casanovas O, Germà JR, Villanueva A, Viñals F.
Int J Cancer. 2013 Jul;133(1):235-46.
2012
Crosstalk between reticular adherens junctions and platelet endothelial cell adhesion molecule-1 regulates endothelial barrier function
Fernández-Martín L, Marcos-Ramiro B, Bigarella CL, Graupera M, Cain RJ, Reglero-Real N, Jiménez A, Cernuda-Morollón E, Correas I, Cox S, Ridley AJ, Millán J.
Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):e90-102. doi: 10.1161/ATVBAHA.112.252080. Epub 2012 Jun 21.
2011
Integrin-dependent and -independent functions of astrocytic fibronectin in retinal angiogenesis
Stenzel D, Lundkvist A, Sauvaget D, Busse M, Graupera M, van der Flier A, Wijelath ES, Murray J, Sobel M, Costell M, Takahashi S, Fässler R, Yamaguchi Y, Gutmann DH, Hynes RO, Gerhardt H.
Development. 2011 Oct;138(20):4451-63. doi: 10.1242/dev.071381. Epub 2011 Aug 31.
2010
The emerging mechanisms of isoform-specific PI3K signalling
Vanhaesebroeck B, Guillermet-Guibert J, Graupera M, Bilanges B.
Nat Rev Mol Cell Biol. 2010 May;11(5):329-41. Review.
2008
Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration
Graupera M, Guillermet-Guibert J, Foukas LC, Phng LK, Cain RJ, Salpekar A, Pearce W, Meek S, Millan J, Cutillas PR, Smith AJ, Ridley AJ, Ruhrberg C, Gerhardt H, Vanhaesebroeck B
Nature. 2008 May 29;453(7195):662-6.
Large-conductance calcium-activated potassium channels modulate vascular tone in experimental cirrhosis
Rodríguez-Vilarrupla A, Graupera M, Matei V, Bataller R, Abraldes JG, Bosch J, García-Pagán JC.
Liver Int. 2008 Apr;28(4):566-73.
2007
Simvastatin treatment improves liver sinusoidal endothelial dysfunction in CCl4 cirrhotic rats
Abraldes JG, Rodríguez-Vilarrupla A, Graupera M, Zafra C, García-Calderó H, García-Pagán JC, Bosch J.
J Hepatol. 2007 Jun;46(6):1040-6. Epub 2007 Feb 15.
Identification and functional characterization of the hepatic stellate cell CD38 cell surface molecule
March S, Graupera M, Rosa Sarrias M, Lozano F, Pizcueta P, Bosch J, Engel P.
Am J Pathol. 2007 Jan;170(1):176-87.
2006
Ultrasensitive and absolute quantification of the phosphoinositide 3-kinase/Akt signal transduction pathway by mass spectrometry
Cutillas PR, Khwaja A, Graupera M, Pearce W, Gharbi S, Waterfield M, Vanhaesebroeck B.
Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):8959-64. Epub 2006 Jun 2.
2005
Sinusoidal endothelial COX-1-derived prostanoids modulate the hepatic vascular tone of cirrhotic rat livers
Graupera M, March S, Engel P, Rodés J, Bosch J, García-Pagán JC.
Am J Physiol Gastrointest Liver Physiol. 2005 Apr;288(4):G763-70. Epub 2004 Nov 18.
2003
Cyclooxygenase-1 inhibition corrects endothelial dysfunction in cirrhotic rat livers
Graupera M, García-Pagán JC, Parés M, Abraldes JG, Roselló J, Bosch J, Rodés J.
J Hepatol. 2003 Oct;39(4):515-21.
Left ventricular hypertrophy in rats with biliary cirrhosis
Inserte J, Perelló A, Agulló L, Ruiz-Meana M, Schlüter KD, Escalona N, Graupera M, Bosch J, Garcia-Dorado D.
Hepatology. 2003 Sep;38(3):589-98.
Cyclooxygenase-derived products modulate the increased intrahepatic resistance of cirrhotic rat livers
Graupera M, García-Pagán JC, Abraldes JG, Peralta C, Bragulat M, Corominola H, Bosch J, Rodés J.
Hepatology. 2003 Jan;37(1):172-81.
Acute propranolol administration effectively decreases portal pressure in patients with TIPS dysfunction. Transjugular intrahepatic portosystemic shunt
Bellis L, Moitinho E, Abraldes JG, Graupera M, García-Pagán JC, Rodés J, Bosch J.
Gut. 2003 Jan;52(1):130-3.
2002
5-lipoxygenase inhibition reduces intrahepatic vascular resistance of cirrhotic rat livers: a possible role of cysteinyl-leukotrienes
Graupera M, García-Pagán JC, Titos E, Claria J, Massaguer A, Bosch J, Rodés J.
Gastroenterology. 2002 Feb;122(2):387-93.
